求人名 Senior Associate, Process Bioscience researcher
勤務地 Tsukuba, Ibaraki
事業部 Gene Therapy Process Science
雇用形態 正社員
仕事内容
【募集の背景 / Purpose & Scope】
Process Science department in Astellas Gene Therapies (AGT), the Center of Excellence in Astellas Pharma., have an opportunity for a Senior Associate to design, develop, optimize, characterize and establish the key elements of rAAV production which meets our quality target product profiles based on a deep understanding of complex manufacturing process. S/he implements experiments with assignments of broad complexity spanning scientific points, design, process evaluation, process engineering, multiple analysis and manufacturing process of rAAV. Through the development of rAAV manufacturing processes that reduce the cost and improve the quality, AGT will bring our gene therapy products to the patients and their families immediately.
【職務の内容 / Essential Job Responsibilities】
（雇入れ直後）
Designs and develop new upstream process by utilizing and/or combining molecular biology, cell biology and chemical biology approaches as well as existing technologies according to AGT’s strategy
- Design the plasmid, its cloning and small-scale production
- Analyzes the critical parameters for rAAV production, such as nutrition, DNA/RNA sequences, biological parameters, metabolome
- Evaluates novel and innovative technology applicable to improve AAV product quality and/or productivity
- Plans experimental designs based on the knowledge of molecular biology as well as upstream process, with appropriate sampling and analytical definition
- Performs design of experiment investigations using software tools for design and data analysis
- Responsible for understanding and applying data generated from experiments and literature used to modify/optimize process parameters
- Assists development of robust and cost-effective commercial scale production processes.
- Writes protocols, development reports, and other technical reports to ensure that results are properly archived and communicated
- Ensures safe and compliant laboratory safety procedures are followed
- Regularly presents data, findings and conclusions to program teams and sub-teams
- Proactively collaborates with consultants and internal stakeholders (Research, PD, AD, Manufacturing, Quality, etc.).
- Establishes and fosters relationships with contract organizations.
（変更の範囲）
会社内での全ての業務
【応募要件 / Qualifications】
＜必須 / Must＞
• Advanced degree in biology or engineering with 3+ years relevant biopharmaceutical industry experience
• Comprehensive experiences and knowledge of development of biopharmaceuticals products
• Success designing and executing experiments to answer scientific questions.
• Operational and experimental knowledge of designing and cloning of the plasmid
• Proven ability to effectively create, communicate, and gain support for execution plans and strategies with a wide range of stakeholders
• Excellent collaboration, problem solving team player with great communication skills including negotiation and conflict resolution skills.
• Able to work in a fast-paced and dynamic environment with competing priorities
• Successful experience working cross-functionally across multiple departments including Research, Manufacturing, and Quality.
• Experience working with external vendors, institutions, and other collaborators to develop and/or evaluate new and disruptive technologies
• Seeks opportunities to improve existing processes and drive large-scale change that positively impacts organizational success.
• Operational and experimental knowledge of upstream process for biologics using shaker flask
• Performs design of experiment investigations using software tools for design and data analysis
• Excellent and effective written, verbal communication and presentation skills.
• Positive, professional attitude with a passion for science.
• Business English level
＜歓迎 / Want＞
• Prior rAAV gene therapy experience
• Operational experience of bioreactors for upstream manufacturing with biologics
• Experience with authoring IND, CTA, and other related regulatory filings and responding to Agency feedback/inquiries
【応募書類 / Application Documents】
和文履歴書・和文職務経歴書・英文レジュメ
Both Japanese and English Resumes are needed
【選考プロセス / Selection details】
書類選考 → 1次面接 → 適性検査 → 最終面接
※変更の可能性もございますので、予めご了承下さい。
CV screening → First interview → Final interview
*Please be advised that there might be a change in the process.
【勤務地 / Location】
（雇入れ直後）
茨城県つくば市 アステラス製薬 つくば研究センター
Tsukuba, Ibaraki
※ＪＲひたち野うしく駅とつくばエクスプレス（TX) 研究学園駅より通勤バスがございます。
（変更の範囲）
会社の定める事業場および自宅
【勤務開始日 / Start Date】
応相談
Will be decided according to the candidate's flexibility
【契約期間 / Contract Duration】
期間の定めなし
Not limited to specified period
【試用期間 / Probation Period】
試用期間原則なし
No probation period in principle
【給与 / Salary】
①基本給：当人の経歴・技術・技能等を考慮して決定
②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給
③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給
①Base salary: will be decided by the candidate's experience, skill and capability.
②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)
③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.
【昇給 / Salary Raise】
有り
【賞与 / Bonus】
有り
【諸手当 / Allowance】
裁量労働手当、住宅手当、通勤手当 等
Discretionary work allowance, Housing allowance, Commutation allowance, etc.
【勤務時間 / Working Hours】
8:30～17:30（月～木）、8:30～15:45（金）、専門業務型 裁量労働制
裁量労働制の場合、所定労働時間を働いたものとみなす。
8:30～17:30（Mon～Thu）、8:30～15:45（Fri）
Discretionary Work System
【休日 / Holidays】
完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始
Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays
【休暇 / Vacation Leave】
年次有給休暇、育児休業制度、介護休業制度 等
Annual paid leave, childcare leave system, nursing care leave system, etc.
【福利厚生 / Welfare】
雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等
Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System
【アステラス製薬 採用サイト/ Career web site】
https://re-jp.astellas.com/jp/recruit/newgraduates/
For more information about Astellas, please visit our career web site.
"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."
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