Astellas Pharma Inc.

【募集の背景 / Purpose & Scope】

Formulation & ADME drives the optimization of drug candidates through globally competitive formulation development, advanced ADME/Safety and formulation strategies from the early stages of oncology drug discovery to clinic. This role provides the strategic guidance on the optimization of drug candidates. ADME/safety/physicochemical properties, accelerates the DMTA cycle through strategic study plan and the delivery of high-quality, high-quantity, and high-speed readouts and supports research leads from safety perspectives, establishing ourselves as a formulation and ADME group with global competitiveness.

【職務の内容 / Essential Job Responsibilities】

（雇入れ直後）

・Act as an outstanding scientist of discovery safety team.

・Provide scientific and strategic direction to optimize drug candidates for efficacy, safety, and ADME properties from Safety perspective for Pre-DC and DC programs.

・Responsible for the analysis, interpretation, integration and reporting of preclinical safety data.

・As part of the integrated teams, design and execute preclinical studies to understand safety properties combined with pharmacokinetics (PK) and pharmacodynamics (PD).

・Clarify safety profiles to optimize compounds based on their safety profiles requirements, ensuring alignment with program timelines and regulatory standards.

・Interact/manage external vendors (CROs, academic sites etc.) for conducting in vivo and in vitro experiments.

・Align with overall Oncology Research strategy and objectives.

・Partner with other functions in Oncology Research as well as Development and Product Research & Development members to translate scientific insights into actionable ADME/safety/formulation strategies.

（変更の範囲）

会社内での全ての業務

【就業環境に関する要件 / Specific Physical or Environmental Requirements】

・This position is based in Japan and requires occasional overseas/domestic business travels.

・At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines.

【応募要件 / Qualifications】

＜必須 / Required＞

・Advanced degree (Ph.D. or equivalent) in Pharmaceutical Sciences, Pharmacology, Veterinary science, or a related field.

・10 years of experience in pharmaceutical or biotech industry, with a focus on safety, preferably within oncology or a related therapeutic area.

・Demonstrated leadership competencies in exploratory safety activities from planning, implementation through completion across multiple programs

・Communication skills (active & passive) in own language and in English.

＜歓迎 / Preferred＞

・External scientific network and reputation, demonstrated by patents, publications and presentations.

・Experience in oncology drug development and familiarity with the unique challenges of targeting cancer therapeutics.

・Extensive experience in safety assessment with multiple therapeutic modalities (e.g. engineered small molecules, peptides, ADCs, multifunctional antibodies).

・Demonstrated expertise in developing and implementing safety screening methods and establishing SARs for small molecule, antibody, and ADC.

【応募書類 / Application Documents】

和文履歴書（必須）・和文職務経歴書（必須）・英文レジュメ（任意）

Resumes

【選考プロセス / Selection details】

書類選考 → 1次面接 → 最終面接

※変更の可能性もございますので、予めご了承下さい。

CV screening → First interview → Final interview

*Please be advised that there might be a change in the process.

【勤務地 / Location】

（雇入れ直後）

茨城県つくば市　アステラス製薬　つくば研究センター

Tsukuba, Ibaraki

※ＪＲひたち野うしく駅とつくばエクスプレス（TX)　研究学園駅より通勤バスがございます。

（変更の範囲）

会社の定める事業場および自宅

【勤務開始日 / Start Date】

応相談

Will be decided according to the candidate's flexibility

【契約期間 / Contract Duration】

期間の定めなし

Not limited to specified period

【試用期間 / Probation Period】

試用期間原則なし

No probation period in principle

【給与 / Salary】

①基本給：当人の経歴・技術・技能等を考慮して決定

②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給

③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給

①Base salary: will be decided by the candidate's experience, skill and capability.

②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)

③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.

【昇給 / Salary Raise】

有り

【賞与 / Bonus】

有り

【諸手当 / Allowance】

裁量労働手当、住宅手当、通勤手当　等

Discretionary work allowance, Housing allowance, Commutation allowance, etc.

【勤務時間 / Working Hours】

8:30～17:30（月～木）、8:30～15:45（金）、専門業務型 裁量労働制

裁量労働制の場合、所定労働時間を働いたものとみなす。

8:30～17:30（Mon～Thu）、8:30～15:45（Fri）

Discretionary Work System

【休日 / Holidays】

完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始

Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays

【休暇 / Vacation Leave】

年次有給休暇、育児休業制度、介護休業制度　等

Annual paid leave, childcare leave system, nursing care leave system, etc.

【福利厚生 / Welfare】

雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度　等

Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System

【アステラス製薬　採用サイト/ Career web site】

https://re-jp.astellas.com/jp/recruit/newgraduates/

For more information about Astellas, please visit our career web site.

"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."