求人名 Bioconjugation Lead
勤務地 Tsukuba, Ibaraki
事業部 Oncology Research
雇用形態 正社員
仕事内容
【募集の背景 / Purpose & Scope】
This pivotal role involves providing strategic, scientific, and operational leadership for our antibody drug conjugate (ADC) research, primarily focusing on bioconjugation strategies and their interplay with antibody characteristics. The position holder will drive the design and development of novel ADC candidates and support the Research Lead (Res-L) from a scientific and resource management perspective to accelerate projects. This position reports directly to the Head of Antibody Drug Conjugate.
【職務の内容 / Essential Job Responsibilities】
（雇入れ直後）
Scientific & Technical Leadership:
-Provide scientific vision, strategic direction, and technical oversight for the Bioconjugation team, ensuring the delivery of well-characterized ADC candidates.
-Collaborate closely with the Antibody Engineering team to define optimal antibody characteristics for conjugation and contribute to the antibody selection strategy for ADC projects
-Lead the design, development, optimization, and execution of novel and established bioconjugation methodologies for creating ADCs, including site-specific conjugation techniques.
-Stay at the forefront of bioconjugation technologies, ADC development, and relevant analytical advancements; evaluate and implement new technologies and approaches to enhance team capabilities and productivity.
-Troubleshoot and resolve complex scientific and technical challenges related to bioconjugation, purification, and characterization
Team Management & Development:
-Lead, manage, mentor, and develop a team, fostering a culture of scientific excellence, innovation, collaboration, urgency, and accountability.
-Ensure appropriate resource allocation, project planning, and timeline management for the Bioconjugation team.
Project & Stakeholder Management:
-Drive bioconjugation aspects of ADC projects from early discovery to development candidate selection, ensuring timely delivery of high-quality data and materials.
-Collaborate effectively with cross-functional teams, including antibody engineering, medicinal chemistry (payload and linker synthesis), analytical development, DMPK, pharmacology, CMC, and external partners.
-Contribute to the preparation of technical reports, patent applications, and regulatory submission documents.
（変更の範囲）
会社内での全ての業務
【応募要件 / Qualifications】
＜必須 / Must＞
-Ph.D. in Chemistry, Biochemistry, Bioengineering, or a closely related field.
-Minimum of 10 years of experience in the biopharmaceutical industry, with a significant portion focused on
Antibody Drug Conjugate development.
-Proven track record of scientific accomplishment and leadership in the biologics field, evidenced by
publications, patents, and successful advancement of therapeutic candidates.
-Significant hands-on experience and deep understanding of protein chemistry, bioconjugation techniques, and
purification methods for proteins and ADCs.
-Experience in identifying, evaluating, and developing novel technologies.
-Proven ability to think strategically and contribute to R&D portfolio planning.
-Excellent communication, interpersonal, and presentation skills, with the ability to effectively communicate
complex science to diverse audiences.
-Demonstrated ability to work collaboratively in a cross-functional, matrixed environment.
-Minimum of 3 years of experience in leading and managing scientific teams.
＜歓迎 / Want＞
-Experience in the development or application of site-specific conjugation technologies
-Knowledge and experience in stability assessment of ADCs, pharmacokinetic (DMPK) characterization, and
in vitro/in vivo efficacy evaluation.
-Experience in the implementation and utilization of high-throughput bioconjugation methods and automation
technologies.
-Knowledge or experience in CMC development of ADCs.
【応募書類 / Application Documents】
和文履歴書・和文職務経歴書・英文レジュメ
Both Japanese and English Resumes are needed
【選考プロセス / Selection details】
書類選考 → 1次面接 → 適性検査 → 最終面接
※変更の可能性もございますので、予めご了承下さい。
CV screening → First interview → Aptitude test → Final interview
*Please be advised that there might be a change in the process.
【勤務地 / Location】
（雇入れ直後）
茨城県つくば市 アステラス製薬 つくば研究センター
Tsukuba, Ibaraki
※ＪＲひたち野うしく駅とつくばエクスプレス（TX) 研究学園駅より通勤バスがございます。
（変更の範囲）
会社の定める事業場および自宅
【勤務開始日 / Start Date】
応相談
Will be decided according to the candidate's flexibility
【契約期間 / Contract Duration】
期間の定めなし
Not limited to specified period
【試用期間 / Probation Period】
試用期間原則なし
No probation period in principle
【給与 / Salary】
①基本給：当人の経歴・技術・技能等を考慮して決定
②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給
③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給
①Base salary: will be decided by the candidate's experience, skill and capability.
②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)
③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.
【昇給 / Salary Raise】
有り
【賞与 / Bonus】
有り
【諸手当 / Allowance】
、住宅手当、通勤手当 等
Discretionary work allowance, Housing allowance, Commutation allowance, etc.
【勤務時間 / Working Hours】
8:30～17:30（月～木）、8:30～15:45（金）、専門業務型 裁量労働制
裁量労働制の場合、所定労働時間を働いたものとみなす。
8:30～17:30（Mon～Thu）、8:30～15:45（Fri）
Discretionary Work System
【休日 / Holidays】
完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始
Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays
【休暇 / Vacation Leave】
年次有給休暇、育児休業制度、介護休業制度 等
Annual paid leave, childcare leave system, nursing care leave system, etc.
【福利厚生 / Welfare】
雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等
Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System
【アステラス製薬 採用サイト/ Career web site】
https://re-jp.astellas.com/jp/recruit/newgraduates/
For more information about Astellas, please visit our career web site.
"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."
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