General Information

Job Advert Title: Medicinal Chemist(Associate Manager - Manager), Venture Unit Tumor-directed inhibition

Location: Tsukuba, Ibaraki

Division: Discovery Accelerator

Employment Class: Permanent


【Purpose & Scope】

Venture Unit (TMDI) conducts research to create first in class PROTAC molecule to degrade undruggable cancer drivers such as Kras active mutants.  To achieve this, TMDI needs qualified medicinal chemists having expertise and motivation on drug design and synthesis of complex and unconventional hetero-bifunctional chemicals.

This position is for a medicinal chemist as a program lead or a major program member to create a differentiating clinical candidate based on new chemical modalities or chemicals conjugated with other modalities.  A person in this position will need to work closely with the program stakeholders in the role of the leadership team in the Unit, program management, chemistry, biology, ADME, and toxicology as well as external partners such as CROs or research collaborators.

Tumor-directed Inhibition Research Unit :

Essential Job Responsibilities

For Associate Manager : 

-Design and synthesize target molecules and analyze assay data for effective drug design as a medicinal chemist with a support by a senior member when necessary.

- Contribute to a program via participating to scientific discussions in program related meetings based on own scientific expertise and external information.

- Be cooperative in the chemistry team as well as with the functional counterparts in the team to promote own research activity in an aligned manner based on the assistance by a senior member.

- Work effectively with external partners including CRO, and research collaborators with a support by a senior member.

- Ensure experimental plans to be complied with internal and external laws, regulations, and compliance standards.

For Manager : 

-Design and synthesize target molecules and analyze assay data for the next drug design as a medicinal chemist

-Manage partnership/CRO to promote a research program effectively

-Participate in program-related meetings and contribute to the progress of the program through the suggestions and discussions

-Be coordinated with researchers in a chemistry team as well as with multiple experts in the area of biology, ADME and toxicology

-Ensure daily experiments to be complied with internal and external laws, regulations, and compliance standards


- PhD or equivalent


For Associate Manager : 

- Ability to propose efficient synthetic routes and synthesize target compounds in a proper manner

- Ability to propose a target molecule to synthesize based on the available data

- An interest and motivation in the drug discovery of PROTAC and related modalities

- Ability to work collaboratively within a team

- Analytical skills and the ability to interpret assay data for new drug design

For Manager : 

- 5+ years of experience as a medicinal chemist in the industry

- An interest and motivation for the drug discovery process and chemical based new modalities

- Ability to design and carry out synthetic experiments safely and accurately

-Analytical skills and the ability to interpret assay data for drug design

- Ability to work collaboratively within a team


For Associate Manager : 

- Experience as a medicinal chemist in the pharma industry

- Communication skills in English

For Manager : 

- Effective project management skills

- Ability and skills on computational simulations for effective drug design

- Problem-solving skills to develop scientific solutions

- Communication skills in English to work with collaborators and CRO partners

【勤務地 / Location

茨城県つくば市 アステラス製薬 つくば研究センター

Tsukuba, Ibaraki

【勤務開始日 / Start Date


Will be decided according to the candidate's flexibility

【契約期間 / Contract Duration


Not limited to specified period

【試用期間 / Probation Period


No probation period in principle

【給与 / Salary




①Base salary: will be decided by the candidate's experience, skill and capability.

②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000~100,000yen, based on the Grade)

③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.

【昇給 / Salary Raise


Once a year

【賞与 / Bonus


Twice a year (July, December)

【諸手当 / Allowance

裁量労働手当、住宅手当、通勤手当 等

Discretionary work allowance, Housing allowance, Commutation allowance, etc.

【勤務時間 / Working Hours

8:30~17:30(月~木)、8:3015:45(金)、専門業務型 裁量労働制



Discretionary Work System

【休日 / Holidays


Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays

【休暇 / Vacation Leave

年次有給休暇、育児休業制度、介護休業制度 等

Annual paid leave, childcare leave system, nursing care leave system, etc.

【福利厚生 / Welfare

雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等

Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System

【お問い合わせ / Contact

アステラス製薬株式会社 採用担当 / Japan Recruiting team, Astellas Pharma Inc.


"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."