Job Advert Title: Medicinal Chemist (Antibody Drug Conjugate)
Location: Tsukuba, Ibaraki
Division: Oncology Research
Employment Class: Permanent
Description
【募集の背景 / Purpose & Scope】
Recent advances in drug discovery targeting cancer have been remarkable, and Astellas is constantly challenging next-generation modalities such as cell therapy, gene therapy, and multifunctional antibodies, as well as new cancer biology. Under such circumstances, we have successfully delivered innovative treatment drugs such as XOSPATA, XTANDI, and PADCEV to cancer patients. Furthermore, we are currently promoting drug discovery research by combining multifunctional modality and the biological understanding of TME in the Primary Focus "Immuno-Oncology" established though our Focus Area approach.
We are urgently recruiting people who will participate in the challenge of driving a paradigm shift in cancer treatment together with our team. We welcome applications from those who can persistently plan and carry out research with innovative ideas and a spirit of challenge, and lead research projects as a member of the global team.
【職務の内容 / Essential Job Responsibilities】
（雇入れ直後）
The position is expected to lead drug discovery programs that utilizes genetically modified technology for cancer treatment, and will be in charge of the following tasks.
1. In view of science and trends in the ADC related field, establish next-generation ADCs that can be expected to have innovative therapeutic benefits
2. Design and synthesis of payloads, linkers and ADCs which includes investigation and analysis of patents, literatures and reviews related to our researching therapeutic area as well as carrying out organic reactions, conjugations, purifications and structure analysis to identify a compound suitable for clinical testing
3. Provides appropriate guidance to younger members on complex issues that arise in ADC research. He/she will also mentor and train younger members of the team in the projects for which he/she is responsible, thereby enhancing the scientific expertise of the team.
4. May be responsible for research outsourced to CROs, such as outsourced synthesis, or in research collaboration with external partners.
5. Contribute to the creation of innovative Oncology Research pipeline through the above ADC research activities.
（変更の範囲）
会社内での全ての業務
【就業環境に関する要件 / Specific Physical or Environmental Requirements】
This position is based in Tsukuba Research center and will require on-site work.
【応募要件 / Qualifications】
＜必須 / Must＞
・ PhD with 5+ years or MS with 8+ years of relevant experience in medicinal chemistry.
・ Strong knowledge of medicinal chemistry
・ Experience in serving as a lead chemist in oncology projects
・ Experimental skills necessary to carry out ADC research (both small molecule synthesis and ADC conjugation)
・ Strong interpersonal and verbal/written communication skills
・ Build strong relationships with peers and partners outside
・ Business level communication skill in English (Japanese communication skill is not mandatory in case applicants are non-Japanese)
【応募書類 / Application Documents】
和文履歴書（必須）・和文職務経歴書（必須）・英文レジュメ（任意）
Resumes
【選考プロセス / Selection details】
書類選考 → 1次面接 → 適性検査 → 最終面接
※変更の可能性もございますので、予めご了承下さい。
CV screening → First interview → Aptitude test → Final interview
*Please be advised that there might be a change in the process.
【勤務地 / Location】
（雇入れ直後）
茨城県つくば市 アステラス製薬 つくば研究センター
Tsukuba, Ibaraki
※ＪＲひたち野うしく駅とつくばエクスプレス（TX) 研究学園駅より通勤バスがございます。
（変更の範囲）
会社の定める事業場および自宅
【勤務開始日 / Start Date】
応相談
Will be decided according to the candidate's flexibility
【契約期間 / Contract Duration】
期間の定めなし
Not limited to specified period
【試用期間 / Probation Period】
試用期間原則なし
No probation period in principle
【給与 / Salary】
①基本給：当人の経歴・技術・技能等を考慮して決定
②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給
③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給
①Base salary: will be decided by the candidate's experience, skill and capability.
②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)
③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.
【昇給 / Salary Raise】
有り
【賞与 / Bonus】
有り
【諸手当 / Allowance】
裁量労働手当、住宅手当、通勤手当 等
Discretionary work allowance, Housing allowance, Commutation allowance, etc.
【勤務時間 / Working Hours】
8:30～17:30（月～木）、8:30～15:45（金）、専門業務型 裁量労働制
裁量労働制の場合、所定労働時間を働いたものとみなす。
8:30～17:30（Mon～Thu）、8:30～15:45（Fri）
Discretionary Work System
【休日 / Holidays】
完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始
Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays
【休暇 / Vacation Leave】
年次有給休暇、育児休業制度、介護休業制度 等
Annual paid leave, childcare leave system, nursing care leave system, etc.
【福利厚生 / Welfare】
雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等
Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System
【アステラス製薬 採用サイト/ Career web site】
https://re-jp.astellas.com/jp/recruit/newgraduates/
For more information about Astellas, please visit our career web site.
"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."
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