Job Advert Title: Global Translational Medicine Lead
Location: Nihonbashi, Tokyo
Division: Early Development
Employment Class: Permanent
Description
【募集の背景 / Purpose & Scope】
Lead the development and execution of Translational Medicine strategy in the development of Astellas’s Cell and Gene Therapy assets. Candidates should have record of accomplishment of developing and executing translational science/medicine programs with mechanistically grounded biomarker and patient selection strategies. Ability to work in cross-functional teams is essential to the success of this position.
【職務の内容 / Essential Job Responsibilities】
（雇入れ直後）
• Develops and executes translational science and biomarker development plans and defines patient selection strategies for clinical studies
• Provides key specifics on the mechanism of action, biomarker identification and patient selection strategies
• Contributes to overall development strategy and trial design, incorporating biomarker endpoints
• Works with clinical team for implementation of biomarker sample collection and bioanalysis
• Drives clinical biomarker data analysis and interpretation
• Contributes to clinical documents: protocols, IBs, study reports, statistical analysis plans, publications, CSR and biomarker sections of regulatory submissions
• Leads reverse translation, so that clinical results can be used to inform development strategy
• Contributes to greater understanding of the mechanism of action to enable clinical translation
• Thinks strategically and drives innovation. Identifies and leads the evaluation of state -of- the- art technologies for translational and biomarker research
• Establishes and leads Translational Medicine focused external collaborations
（変更の範囲）
会社内での全ての業務
【応募要件 / Qualifications】
＜必須 / Required＞
• Advanced science degree (PhD, PharmD, or MD) with primary focus in human genetics, molecular biology, or virology
• A minimum of 7 years relevant experience in drug discovery and development in biotech/pharmaceutical company or equivalent translational research experience at an academic institution.
• Broad knowledge and first-hand experience in translational development of gene therapy or cell therapy
• Extensive experience in clinical biomarker assay development, qualification and clinical implementation
• Proven record of leading teams and obtaining high quality and timely results through influencing in a matrix environment
• Demonstrated success in delivering high quality clinical biomarker data to inform decisions and development strategy
• Broad technical experience in DNA, RNA, and protein-based biomarker assays (e.g. PCR, NGS, ELISA/MSD, IHC)
• An innovation mindset with track record of incorporating new technologies in translational and biomarker research
• Strong communication skills (oral, written, and presentations), interpersonal, influencing, and overall leadership skills
＜歓迎 / Preferred＞
• Translational development experience in rare diseases
• Experience in managing CRO work
【応募書類 / Application Documents】
和文履歴書・和文職務経歴書・英文レジュメ
Both Japanese and English Resumes are needed
【選考プロセス / Selection details】
書類選考 → 1次面接 → 最終面接
※変更の可能性もございますので、予めご了承下さい。
CV screening → First interview → Final interview
*Please be advised that there might be a change in the process.
【勤務地 / Location】
（雇入れ直後）
東京都中央区 アステラス製薬 日本橋事業所 本社
Nihonbashi, Tokyo
（変更の範囲）
会社の定める事業場および自宅
【勤務開始日 / Start Date】
応相談
Will be decided according to the candidate's flexibility
【契約期間 / Contract Duration】
期間の定めなし
Not limited to specified period
【試用期間 / Probation Period】
試用期間原則なし
No probation period in principle
【給与 / Salary】
①基本給：当人の経歴・技術・技能等を考慮して決定
②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給
③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給
①Base salary: will be decided by the candidate's experience, skill and capability.
②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)
③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.
【昇給 / Salary Raise】
有り
【賞与 / Bonus】
有り
【諸手当 / Allowance】
裁量労働手当、住宅手当、通勤手当 等
Discretionary work allowance, Housing allowance, Commutation allowance, etc.
【勤務時間 / Working Hours】
8:45～17:45（月～木）、8:45～16:00（金）、企画業務型 裁量労働制
裁量労働制の場合、所定労働時間を働いたものとみなす
8:45～17:45（Mon～Thu）、8:45～16:00（Fri）
Discretionary Work System
【休日 / Holidays】
完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始
Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays
【休暇 / Vacation Leave】
年次有給休暇、育児休業制度、介護休業制度 等
Annual paid leave, childcare leave system, nursing care leave system, etc.
【福利厚生 / Welfare】
雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等
Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System
【アステラス製薬 採用サイト/ Career web site】
https://re-jp.astellas.com/jp/recruit/newgraduates/
For more information about Astellas, please visit our career web site.
"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."